When local antioxidant systems fail, oxidative damage permanently occurs to lipids of cellular membranes, proteins, and DNA. In nuclear and mitochondrial DNA, 8-OHdG is predominantly formed due to free radical- induced oxidative (pro-mutative) lesions.
A biomarker of oxidative stress associated with:
8-OHdG is also used to estimate the DNA damage in humans after exposure to cancer-causing agents, such as tobacco smoke, asbestos fibers, heavy metals, and polycyclic aromatic hydrocarbons.
60 women with malignant tumors in a breast cancer study1 and 82 men in a prostate cancer study showed8-OHdG levels significantly higher than controls2. Levels did not decrease with prostatectomy but did decrease with androgen suppression hormone therapy.