DUTCH Testing

DUTCH DNA Stress Test

What Happens?

When local antioxidant systems fail, oxidative damage permanently occurs to lipids of cellular membranes, proteins, and DNA. In nuclear and mitochondrial DNA, 8-OHdG is predominantly formed due to free radical- induced oxidative (pro-mutative) lesions.

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A biomarker of oxidative stress associated with:

  • High Cortisol
  • High Blood Pressure
  • Diabetes
  • Cystic Fibrosis
  • Atopic Dermatitis
  • Rheumatoid Arthritis
  • Parkinson’s Disease
  • Alzheimer’s Disease
  • Huntington’s Disease
  • Pancreatitis • Chronic Hepatitis
  • Breast Cancer and other Various Cancers

8-OHdG is also used to estimate the DNA damage in humans after exposure to cancer-causing agents, such as tobacco smoke, asbestos fibers, heavy metals, and polycyclic aromatic hydrocarbons.

Studies & Cancer

60 women with malignant tumors in a breast cancer study1 and 82 men in a prostate cancer study showed8-OHdG levels significantly higher than controls2. Levels did not decrease with prostatectomy but did decrease with androgen suppression hormone therapy.

Treatment Ideas When Elevated

  • Address the cause
  • Reduce stress and avoid toxins.
  • Encourage increased intake of fruits and vegetables.
  • Support antioxidant status. (Vit. C, Melatonin, Vit. E)
  • Assess and evaluate glutathione (N-Acetyl Cysteine).